The Best Estrogen Blockers for Men: How Aromatase Inhibitors Work

RevMan 5.3 was used for comparing MD of the different primary and secondary outcomes between AIs and the control groups. Limitations to our study include the retrospective design, but all data were collected prospectively. The study does have limited external validity as data were obtained from a single institution and single provider. We also did not discern nor account for possible physiologic differences in men on AZ on clomiphene citrate versus those on exogenous TTH. We were not able to validate if AZ or clomiphene citrate did not interfere Finasteride with E2 immunoassay testing. Furthermore all men did not have measurements completed by LCMS but were included in order to obtain a reasonable sample size.

DIM is generally well-tolerated, with minimal side effects compared to conventional aromatase inhibitors. In this article, we’ll explore how DIM works, its potential benefits for managing estrogen on TRT, and why it may be a viable alternative to traditional aromatase inhibitors. Because we are the best online TRT clinic, we create a Testosterone Replacement Therapy program built around your body and goals.

• Because we are the best online TRT clinic, we create a Testosterone Replacement Therapy program built around your body and goals.
• But if things are out of balance it can lead to excess estrogen, especially as you age.
• Healthy young men who followed a zinc-restricted diet for 20 weeks experienced a drastic decrease in total testosterone levels, falling to a mere 25% of baseline values 5.
• Therefore, inhibiting beta-glucuronidase (via calcium D-glucarate) may help lower levels of estradiol and estrogen metabolites by increasing their rate of elimination 17.

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Seventeen individuals entered the study, all of whom completed the protocol with no significant adverse events reported. The first treatment phase was anastrozole in nine subjects and placebo in the remaining eight. Six participants consented to paired sc adipose biopsies at the completion of each treatment period.

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However, this arm was excluded from the analysis as our study wanted to compare the outcomes regarding the daily use of aromatase inhibitors. The details of the RCTs included in this meta-analysis have been elaborated in Table 1. The outcomes of the uncontrolled studies have been summarized in Table 2 as a part of the systematic review. And lastly, always consult with a licensed physician, preferably one specializing in hormone replacement therapy, before taking a prescription estrogen blocker.

Given the importance of E2 in male physiology and the impact of TTH on E2, careful monitoring by practitioners providing exogenous therapy is critical. Beta-glucuronidase is produced by bacteria in the colon and is responsible for breaking down certain carbohydrates. Excessive activity of this enzyme has been shown to decrease the rate at which estrogen metabolites are removed from the body 16. 3,3′-diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables (e.g. broccoli and cauliflower). DIM appears to modulate estrogen metabolism by acting on the aryl-hydrocarbon receptor that regulates gene expression in men and women 12.

We hope the information will be useful for you to become more educated about your health care decisions. Too little estrogen can cause joint pain, low libido, depression, and cardiovascular risks. Jonathan V. Wright is medical director and founder of the Tahoma Clinic and Meridian Valley Labs. Numerous natural product extracts have been tested and evaluated, mostly from edible plants and fungi, though also including spices, teas, coffees and cycads. However, the vast majority of this has been tested in vitro – in cell studies.

The number of natural products, extracts, and compounds is innumerable, so I’ve focused just on the top ten products, extracts or compounds of each category that has a high in vivo and/or in vitro activity/efficacy. I’ve then narrowed this down to find which compounds/extracts out of this list contain clinical studies with effectiveness, which led me to 9 natural products of most interest. Below I include a table of the said natural products, compounds and extracts that I’ve followed up for this blog, ranked from the most effective at reducing or modulating oestrogen at the top, down to not enough recorded clinical data present at the bottom.

A subsequent large randomized trial, the Study of Tamoxifen and Raloxifene, which was also sponsored by NCI, found that 5 years of raloxifene (a SERM) reduces breast cancer risk in such women by about 38% (27). Most breast cancers are ER positive, and clinical trials have tested whether hormone therapy can be used to prevent breast cancer in women who are at increased risk of developing the disease. Not all of these roles of the enzyme described in animal studies have been ascertained in humans. Available data also indicate that brain aromatase expression is altered with aging and under neurodegenerative conditions. Further, genetic and neuropathological findings suggest that the enzyme may participate in the manifestation of brain diseases, including major depressive disorder, autism spectrum disorders (ASDs), and neurodegenerative diseases.

Tamoxifen changes the enzymes in the liver, preventing many necessary processes in the body from functioning correctly. Tamoxifen has also been shown to cause vision problems and increase the likelihood of thromboembolic events. Because this hormone therapy is used primarily with women, much more is known about its efficacy in that demographic.